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SARS in newborns and children

Pak C Ng1, Chi W Leung, Wah K Chiu

  • 1Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. pakcheungngcuhk.edu.hk

Biology of the Neonate
|June 26, 2004
PubMed

Insights

Severe acute respiratory syndrome (SARS) in children presents differently than in adults. This review details SARS-CoV infection in pediatric patients, noting a less severe clinical course and no reported fatalities in this age group.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Virology

Background:

  • Severe acute respiratory syndrome (SARS) is a contagious illness caused by the SARS coronavirus (SARS-CoV).
  • While vertical transmission is unlikely, some infants born to SARS-positive mothers experienced intrauterine growth retardation and gastrointestinal issues.
  • Clinical presentation and prognosis of SARS differ significantly between pediatric and adult populations.

Purpose of the Study:

  • To review the clinical manifestations, diagnostic approaches, immunological findings, management strategies, and outcomes of SARS-CoV infection specifically in the pediatric population.

Main Methods:

  • This review synthesizes current knowledge on pediatric SARS.
  • Information was gathered on clinical symptoms, diagnostic tests, immune responses, treatment, and patient outcomes.

Main Results:

  • Pediatric SARS-CoV infection generally follows a less aggressive clinical course compared to adults.
  • Young children (<12 years) exhibit milder symptoms than older children and adults.
  • No fatalities have been reported in the pediatric age group (≤18 years) to date.

Conclusions:

  • SARS-CoV infection in children has distinct characteristics compared to adults.
  • Understanding these pediatric-specific aspects is crucial for appropriate diagnosis and management.
  • The generally milder course and favorable prognosis in children warrant specific attention in public health and clinical guidelines.

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