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Safety evaluation of dibenzyl ether.

G A Burdock1, R A Ford

  • 1Flavor and Extract Manufacturers' Association, Washington, DC 20006.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|July 1, 1992
PubMed
Summary

Dibenzyl ether showed no toxicological effects in rats after 91 days of dietary administration. A no-effect level was established, indicating a significant safety margin for human consumption.

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Area of Science:

  • Toxicology
  • Food Safety
  • Chemical Safety

Background:

  • Dibenzyl ether (CAS No. 103-50-4) is a substance used in various applications.
  • Assessing the safety of food additives and chemicals is crucial for public health.

Purpose of the Study:

  • To evaluate the subchronic toxicity of dibenzyl ether when administered orally to rats.
  • To determine a no-observed-adverse-effect level (NOAEL) for dibenzyl ether.

Main Methods:

  • Rats were fed dibenzyl ether in their diet at doses of 62, 196, or 620 mg/kg/day for 91 consecutive days.
  • Body weight, food consumption, hematology, clinical chemistry, urinalysis, gross pathology, and organ weights were assessed.
  • Microscopic pathology was also examined.

Main Results:

  • Increased absolute and relative liver weights were observed in high-dose females, considered a dose-related adaptive change.
  • Sporadic statistically significant events unrelated to dose were noted and deemed normal adaptive changes.
  • No toxicological or pathological effects were observed at any dose level after 91 days.

Conclusions:

  • Dibenzyl ether did not cause toxicological or pathological effects in rats after 91 days of dietary exposure.
  • A no-effect level was established at 196 mg/kg/day.
  • High safety factors were calculated based on estimated human intake, suggesting a wide margin of safety.

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