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Updated: Jul 26, 2026

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
Leptomeningeal precursor B-cell lymphoblastic lymphoma in a child with minimal bone marrow involvement
Oussama Abla1, Ahmed Naqvi, Charles Ye
1University of Toronto, Division of Hematology/Oncology, The Hospital for Sick Children, ON, Canada. oussama.abla@sickkids.ca
Abstract:
The authors report an unusual presentation of a leptomeningeal lymphoblastic lymphoma in a 6-year-old boy with headache and papilledema as the only initial manifestations. The diagnosis was confirmed by the presence of precursor B-cell lymphoblasts in the cerebrospinal fluid, with no cerebral mass and with only 9% phenotypically identical blasts in the bone marrow. This patient was treated on a high-risk ALL protocol with intensive systemic/intrathecal chemotherapy plus cranial irradiation, and he remained in complete remission 6 months after his initial diagnosis.
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