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Related Experiment Videos

Plexin-B3 is a functional receptor for semaphorin 5A.

Stefania Artigiani1, Paolo Conrotto, Pietro Fazzari

  • 1Institute for Cancer Research and Treatment (IRCC), University of Torino--Medical School, 10060 Candiolo (TO), Italy.

EMBO Reports
|June 26, 2004
PubMed
Summary

Semaphorin 5A (Sema5A) binds to plexin-B3, a specific receptor. This interaction triggers cellular responses, including activating the Met receptor, revealing Sema5A

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Area of Science:

  • Molecular biology
  • Cell signaling
  • Neuroscience

Background:

  • Semaphorins are crucial molecular cues in neural development.
  • Semaphorin 5A (Sema5A), a transmembrane semaphorin, regulates axon guidance.
  • The specific receptor for Sema5A has not been fully identified.

Purpose of the Study:

  • To identify the high-affinity receptor for Semaphorin 5A (Sema5A).
  • To investigate the functional consequences of Sema5A-plexin-B3 interaction.
  • To explore the signaling pathways activated by Sema5A.

Main Methods:

  • Binding assays to determine receptor specificity.
  • Cell-based assays to assess functional responses.
  • Co-immunoprecipitation to analyze receptor complexes.

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Main Results:

  • Plexin-B3 was identified as the specific high-affinity receptor for Sema5A.
  • Sema5A binding to plexin-B3 induced functional responses in various cell types.
  • Sema5A also activated the Met receptor signaling pathway when complexed with plexin-B3.

Conclusions:

  • Plexin-B3 is the primary receptor mediating Sema5A functions.
  • Sema5A elicits diverse cellular responses via plexin-B3.
  • Sema5A signaling involves crosstalk with the Met receptor pathway.