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Related Experiment Videos

Signalling: basics and evolution.

Robert J P Williams1

  • 1Inorganic Chemistry Laboratory, University of Oxford, Oxford, UK. bob.williams@chemistry.oxford.ac.uk

Acta Biochimica Polonica
|June 26, 2004
PubMed
Summary
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Cellular signalling involves information transfer from DNA and the environment to metabolism, which then signals back. This process evolved, making the brain a phenotypic organ interacting with environmental information.

Area of Science:

  • Cell Biology
  • Evolutionary Biology
  • Biochemistry

Background:

  • Signalling is crucial for cellular organization, but the nature of 'information' in cell biology is unclear.
  • The assumption that DNA solely encodes cellular information is insufficient.
  • Environmental factors also contribute significant information for cellular processes.

Purpose of the Study:

  • To clarify the concept of information transfer in cellular signalling.
  • To investigate the roles of DNA and the environment as information sources.
  • To trace the evolution of signalling from prokaryotes to humans.

Main Methods:

  • Comparative analysis of signalling mechanisms across different organisms.
  • Examination of metabolic pathways as information receivers and transmitters.

Related Experiment Videos

  • Tracing the evolutionary trajectory of environmental information integration.

    • Main Results:

    • The environment serves as a critical secondary source of information (material and energy) for cells.
    • General metabolism acts as the primary receiver for information from both DNA and the environment.
    • Metabolism actively signals back to both DNA and environmental uptake systems.
    • Evolution shows an increasing reliance on environmental information, culminating in the brain's phenotypic nature.

    Conclusions:

    • Cellular signalling is a complex interplay between genetic and environmental information.
    • Metabolism is central to processing and relaying information within the cell.
    • The evolution of multicellularity and complex organisms is linked to the integration of environmental cues through signalling.