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Updated: Aug 23, 2026
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
[Sudden blindness of 11-year old boy in the course of acute lymphoblastic leukemia]
Dorota Pojda-Wilczek1, Ewa Herba, Barbara Zatorska
1Katedry i Oddziału Klinicznego Okulistyki Slaskiej Akademii Medycznej w Katowicach, Szpital Specjalistyczny nr 1 w Bytomiu.
Purpose:
The aim of this study is to present dramatic ocular manifestation of acute lymphoblastic leukemia.
Material And Methods:
The 11 years old boy was hospitalized due to acute leukemia at the Department and Clinic of Pediatric Hematology, and was referred to ophthalmic examination because of sudden blindness of the right eye. General ophthalmic examination and electrophysiological tests were done.
Results:
No light perception of right eye, and markedly reduced visual evoked responses were caused by infiltration with great edema in optic nerve and its surrounding of retina. In spite of the fact, that the infiltrations disappeared after general therapy, the vision did not recover at all.
Conclusions:
Even intensive treatment may be ineffective in blindness prevention in severe course of acute leukemia.
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