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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: Mar 1, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Bone marrow cells and myocardial regeneration.

Fu-Sheng Wang1, Cathy Trester

  • 1R&D Department, Sysmex America, Mundelein, Illinois 60060, USA. wangf@sysmex.com

International Journal of Hematology
|June 29, 2004
PubMed
Summary

Hematopoietic stem cell (HSC) plasticity enables bone marrow stem cells to regenerate heart tissue. This review focuses on the clinical application of these cells for myocardial regeneration, offering hope for heart disorder treatments.

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Cardiovascular Research

Background:

  • Hematopoietic stem cell (HSC) plasticity allows differentiation into various tissues.
  • Myocardial infarction poses significant health risks, driving the need for cardiac regeneration strategies.
  • Bone marrow stem cells are being explored for their potential in repairing damaged heart tissue.

Purpose of the Study:

  • To review the clinical applications of hematopoietic stem cell (HSC) plasticity in regenerative medicine.
  • To focus on the use of bone marrow cells for myocardial regeneration.
  • To summarize recent findings on HSC-based cardiac repair.

Main Methods:

  • Review of preclinical animal studies on HSC-based myocardial regeneration.
  • Analysis of reported clinical study results from the past 2 years.

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  • Examination of cell surface markers and treatment efficacy in transplanted cells.

    • Main Results:

    • Preclinical data suggest HSCs can reconstruct cardiac vasculature, muscle, and function.
    • Clinical study results on myocardial regeneration using HSCs are emerging.
    • Increased reports of myocardial regeneration treatments utilizing HSCs were observed in 2003.

    Conclusions:

    • HSC plasticity offers a promising avenue for myocardial regeneration.
    • Bone marrow cell transplantation is a key focus for treating heart disorders.
    • Further clinical investigations are warranted to optimize HSC-based cardiac repair therapies.