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Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric
S Arinaga1, N Karimine, K Takamuku
1Department of Surgery, Kyushu University, Beppu, Japan.
International Journal of Immunopharmacology
|May 1, 1992
Abstract:
In 15 patients with gastric carcinoma, peripheral blood mononuclear cells (PBM) were obtained serially before and 3, 5 and 7 days after lentinan administration. The generation of lymphokine-activated killer (LAK) activity, induced by in vitro activation of PBM with interleukin 2 (IL 2), was significantly augmented 5 days after a single intravenous dose of 2 mg lentinan, when compared with that before lentinan injection. Natural killer (NK) activity of PBM was also significantly enhanced 7 days after the drug injection. However, the distribution of lymphocyte subsets exhibited no significant change following lentinan administration.