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Distribution of 99mTc-labeled lymphocytes in control and inflamed rats
Alessandro Fulgenzi1, Rosangela Casati, Fabio Riccardo Colombo
1Istituto di Patologia Generale, Universita degli Studi di Milano, Milano, Italy.
Abstract:
We studied the in vivo fate of CD8(+) lymphocytes, of naive (CD8(+)CD45RC(bright)) or memory (CD8(+)CD45RC(dim)) phenotype, injected in syngeneic rats, after their sorting and labeling with [(99m)Tc] HM-PAO. By using the scintigrafic method we showed that memory CD8(+) lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.
