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Updated: Aug 23, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
Genetic dissection of antigen receptor induced-NF-kappaB activation
Zhi-Wei Li1, Robert C Rickert, Michael Karin
1H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 3011 West Holly Drive, SRB-22344, Tampa, FL 33612, USA. liz@moffitt.usf.edu
Abstract:
NF-kappaB is a master transcription factor in the immune system. It regulates various aspects of immune cell development, homeostasis, survival and function. It is in these contexts that the signaling pathways leading to NF-kappaB activation are best understood. This review addresses the cell signaling from antigen receptors as well as Toll-like receptors to NF-kappaB in both innate and adaptive immunity as revealed by the analysis of mice lacking specific signaling intermediates.
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