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A convenient method for regional monoamine oxidase-A determination by [14C]clorgyline autoradiography
M Murakami1, Y Kondoh, Y Weimin
1Department of Radiology, Research Institute for Brain and Blood Vessels-Akita, Japan.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|August 1, 1992
Abstract:
The availability of clorgyline for regional monoamine oxidase-A (MAO-A) determination was examined using [14C]clorgyline in rat. [14C]Clorgyline was synthesized by the methylation reaction of N-desmethyl-clorgyline and [14C]methyliodide in dimethylformamide with high radiochemical yield. The MAO-A distribution map by autoradiography correlated with that by histochemical technique and its quantity was consistent with the calculated MAO-A amount based on previous reports. The combination of labeled clorgyline and autoradiographic technique will promise the quantitative measurement of regional MAO-A distribution.