Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nomogram to estimate age-related MAC.

J G C Lerou1

  • 1Radboud University Nijmegen, Department of Anaesthesia, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands. j.lerou@anes.umcn.nl

British Journal of Anaesthesia
|June 29, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasound-guided needle handling using a guidance positioning system in a phantom.

Anaesthesia·2013
Same author

The pharmacokinetics of ropivacaine after four different techniques of brachial plexus blockade.

Anaesthesia·2007
Same author

Applying a physiological model to quantify the delay between changes in end-expired concentrations of sevoflurane and bispectral index.

British journal of anaesthesia·2007
Same author

Model-based administration of inhalation anaesthesia. 3. Validating the system model.

British journal of anaesthesia·2002
Same author

Model-based administration of inhalation anaesthesia. 4. Applying the system model.

British journal of anaesthesia·2002
Same journal

Eye-tracking technology applied to regional anaesthesia task performance, safety and skill acquisition: a scoping review.

British journal of anaesthesia·2026
Same journal

Psychological factors associated with postoperative cognitive outcomes in older adults: reconciling adjusted effect estimates with P-value synthesis. Comment on Br J Anaesth 2026; 136: 1482-94.

British journal of anaesthesia·2026
Same journal

The long and winding road: a longitudinal study of UK anaesthetists in training.

British journal of anaesthesia·2026
Same journal

Association of cumulative fluid balance trajectories with haemodynamics, inflammation, and long-term mortality in critically ill patients with circulatory failure: bridging physiology and causal inference with target trial emulation. Comment on Br J Anaesth 2026; 136: 542-51.

British journal of anaesthesia·2026
Same journal

Risk of perioperative cardiorespiratory complications and mortality associated with preoperative glucagon-like peptide-1 receptor agonist use in type 2 diabetes mellitus. Comment on Br J Anaesth 2026; 136: 86-97.

British journal of anaesthesia·2026
Same journal

Hypotension and pulmonary atelectasis during general anaesthesia: a randomised crossover laboratory study.

British journal of anaesthesia·2026
See all related articles

A new nomogram simplifies estimating anesthetic requirements. This tool quickly calculates age-corrected Minimum Alveolar Concentration (MAC) multiples and required end-expired agent concentrations for volatile anesthetics and nitrous oxide.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Clinical Anesthesia

Background:

  • Accurate estimation of anesthetic depth is crucial in clinical practice.
  • Calculating age-corrected Minimum Alveolar Concentration (MAC) and required end-expired agent concentrations can be challenging.
  • Existing methods for determining anesthetic requirements are often time-consuming.

Purpose of the Study:

  • To develop a simplified tool for estimating anesthetic requirements.
  • To provide a rapid method for calculating age-corrected MAC multiples.
  • To determine the precise end-expired volatile agent concentration for a target MAC multiple.

Main Methods:

  • Developed a single nomogram using standard nomogram techniques.
  • The nomogram covers a wide range of patient ages (1-100 years) and MAC values (0.1-1.8).

Related Experiment Videos

  • Included common volatile anesthetics (halothane, enflurane, isoflurane, sevoflurane, desflurane) and nitrous oxide.

    • Main Results:

    • The nomogram allows for rapid estimation of anesthetic requirements with simple graphical methods.
    • Demonstrated specific examples of achieving target MAC multiples across different ages and agent combinations.
    • Showcased the nomogram's utility in both calculating MAC from concentrations and determining concentrations for a desired MAC.

    Conclusions:

    • The developed nomogram provides accurate and easily obtainable results for anesthetic management.
    • The nomogram is user-friendly, requiring only the drawing of two straight lines.
    • The nomogram's design is adaptable for other anesthetic agents, such as xenon.