Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke.

Thomas Kucinski1, Amitava Majumder, René Knab

  • 1Department of Neuroradiology, University-Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany. kucinski@uke.uni-hamburg.de

Neuroradiology
|June 29, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cisplatin-based chemotherapy is a possible risk factor for cerebral stroke in patients with testicular germ cell tumour - a case report and review of the literature.

Journal of chemotherapy (Florence, Italy)·2026
Same author

A corona-like distribution and patchy pattern of cerebellar infarcts identify patients with giant cell arteritis.

Therapeutic advances in neurological disorders·2026
Same author

A New Fibrin-Heparine Coated Self-Expanding Stent for the Rescue Treatment of Intracranial Stenosis-a Multicentric Study.

Clinical neuroradiology·2024
Same author

Prospective evaluation to characterize the real-world performance of the EMBOVAC aspiration catheter for neurothrombectomy: a post-market clinical follow-up trial.

Journal of neurointerventional surgery·2024
Same author

First experience with Walrus balloon guide catheter in a whole-body flow model.

Neuroradiology·2023
Same author

The Clinical Features of Dissection of the Cervical Brain-Supplying Arteries.

Deutsches Arzteblatt international·2022
Same journal

Increased free interstitial fluid in the normal appearing brain in idiopathic normal pressure and post-hemorrhagic hydrocephalus despite unchanged choroid plexus size.

Neuroradiology·2026
Same journal

Application of angiotensin-converting-enzyme inhibitors in endovascular treatment of intracranial aneurysms.

Neuroradiology·2026
Same journal

Enhanced detection of subtle cortical abnormalities in focal epilepsy using 7 T MRI surface-based models and graph neural networks.

Neuroradiology·2026
Same journal

Anterior cerebral artery variants and their influence on endovascular outcomes: a propensity score matched analysis from the CRETA registry.

Neuroradiology·2026
Same journal

Super-resolution deep learning reconstruction for brain fluid-attenuated inversion recovery: image quality and white matter hyperintensity volume analysis.

Neuroradiology·2026
Same journal

Deep learning for contrast-enhanced MRI in pediatric brain imaging.

Neuroradiology·2026
See all related articles

Early signs of ischemic stroke on CT scans correlate with perfusion impairment. Reduced cerebral blood flow (CBF) severity directly impacts early ischemic edema (EIOE) on CT and diffusion changes.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Early ischemic signs on CT scans appear within 6 hours of ischemic stroke.
  • These early changes are subtle and related to water uptake in brain tissue.
  • Quantifying these changes aids in understanding stroke pathophysiology.

Purpose of the Study:

  • To test the hypothesis that the severity of perfusion impairment correlates with the degree of CT density decrease.
  • To investigate the relationship between early ischemic edema (EIOE) and perfusion parameters.
  • To elucidate the pathophysiology of early ischemic changes on CT.

Main Methods:

  • Correlating CT density decrease with apparent diffusion coefficient (ADC) decrease.
  • Superimposing regions of decreased ADC and CT density on magnetic resonance perfusion images in 29 acute-stroke patients.

Related Experiment Videos

  • Analyzing the correlation between mean values of ADC and CT density decrease with relative cerebral blood flow (rCBF), cerebral blood volume (rCBV), mean transit time (rMTT), and time-to-peak (rTTP).

    • Main Results:

    • A linear correlation was found between CT density decrease and rCBF (0.42, p < 0.01) and rCBV (0.62, p < 0.01).
    • The average CT density decrease was 1.2 +/- 0.6 Hounsfield units.
    • No significant correlation was observed between CT density decrease and prolonged rMTT (1.43, p = 0.78) or rTTP (1.34, p = 0.26).

    Conclusions:

    • Reduced rCBF is the primary determinant of the severity of early ischemic edema (EIOE) on CT scans.
    • The reduction in CT density and ADC decrease are directly influenced by the severity of rCBF reduction.
    • These findings offer a unified perspective on the pathophysiology of EIOE.