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Relationship between serum calcium and CA 19-9 levels in colorectal cancer
Peter Fuszek1, Peter Lakatos, Adam Tabak
11st Department of Medicine, Faculty of Medicine, Semmelweis University, 1083 Budapest, Koronyi S. u. 2/a, Hungary. fuszpet@bel1.sote.hu
Aim:
To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients.
Methods:
Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above.
Results:
A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined.
Conclusion:
Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer.
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