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Updated: Aug 23, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
Published on: December 27, 2017
The concentration of circulating megakaryocyte progenitors in preterm neonates is a function of post-conceptional age
Matthew A Saxonhouse1, Robert D Christensen, Danielle M Walker
1Division of Neonatology, Department of Pediatrics, University of Florida, College of Medicine, P.O. Box 100296, Gainesville, FL 32610-0296, USA. saxonma@peds.ufl.edu
Abstract:
Circulating megakaryocyte (Mk) progenitors have been used as a measure of megakaryocytopoiesis in neonates. Prior studies have shown a gestational age-dependent decrease in their concentration, but it is unclear how this process continues after birth in preterm neonates. To answer this question, we quantified the Mk progenitors in the blood of 42 neonates of varying post-conceptional ages (gestational age+days of life). We found an inverse relationship between concentration of circulating Mk progenitors and post-conceptional age (r=-0.54, p=0.0002).
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