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Effects of high-dose RU-486 treatment on climacteric complaints in hysterectomized postmenopausal women: a 6-week

Marieke O Verhoeven, Marius J van der Mooren, Herjan J T Coelingh Bennink

    European Journal of Obstetrics, Gynecology, and Reproductive Biology
    |June 30, 2004
    PubMed

    We investigated the effect of the anti-progestogen mifepristone (RU-486) on climacteric complaints. Four hysterectomized postmenopausal women, with at least 35 hot flushes per week, were treated with daily 200mg RU-486 for 6 weeks. RU-486 did not significantly improve climacteric complaints. Although this result does not support further clinical research with this dose of RU-486 for the treatment of climacteric complaints, potential effects of higher, but more interestingly of lower, dosages of RU-486 cannot be excluded.

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