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Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis
Mathula Thangarajh1, Andreia Gomes, Thomas Masterman
1Neurotec Department, Division of Neurology R54, Karolinska Institutet at Huddinge University Hospital, SE-141 86 Stockholm, Sweden. Mathula.Thangarajh@neruotec.ki.se
Abstract:
The role of B cells and antibodies in the pathogenesis of multiple sclerosis (MS) is controversial. We investigated the expression of B-cell-activating factor of the tumor necrosis factor family (BAFF), a protein indispensable for B-cell survival, and of its three receptors in MS patients and controls. BAFF mRNA levels in monocytes, and BAFF-receptor mRNA in B and T cells, were higher in patients than in healthy controls; yet, BAFF protein levels in cerebrospinal fluid and plasma were similar in patients and headache controls. In addition, each MS disease course was associated with a unique expression pattern for all four molecules.
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