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The Nordic Reference Interval Project 2000: recommended reference intervals for 25 common biochemical properties.

P Rustad¹, P Felding, L Franzson

¹Fürst Medical Laboratory, Søren Bulls vei 25, NO-1051 Oslo, Norway. prustad@furst.no

Scandinavian Journal of Clinical and Laboratory Investigation

|June 30, 2004

Summary

This study established common reference intervals for 25 clinical biochemistry analytes across 102 Nordic laboratories. These new reference intervals aim to standardize clinical laboratory testing for improved patient care in the Nordic region.

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Area of Science:

Clinical Biochemistry
Laboratory Medicine
Reference Interval Establishment

Background:

Routine clinical biochemistry laboratories require standardized reference intervals for accurate interpretation of patient results.
Existing reference intervals can vary significantly between laboratories and regions, impacting diagnostic consistency.

Purpose of the Study:

To establish common, harmonized reference intervals for 25 frequently requested serum/plasma analytes in the Nordic countries.
To facilitate consistent and reliable clinical laboratory testing across the Nordic region.

Main Methods:

Collection of blood samples from 102 healthy reference individuals per laboratory, evenly distributed by gender and age.
Analysis of 25 common serum/plasma components using traceable reference methods and control materials.
Centralized database for evaluation and calculation of reference intervals.

Main Results:

Established reference intervals for 25 key clinical biochemistry analytes.
Data collected from 102 Nordic clinical biochemistry laboratories.
Parallel analysis of hematology properties and storage of samples for future studies.

Conclusions:

The study provides a foundation for harmonized clinical laboratory diagnostics in the Nordic region.
The established reference intervals are intended for common use, promoting consistency in patient care.
Future research can leverage stored samples for additional reference interval determinations.