Nordic Reference Interval Project Bio-bank and Database (NOBIDA): a source for future estimation and retrospective...

Area of Science:

• Clinical Biochemistry
• Biobanking
• Reference Interval Development

Background:

• The Nordic Reference Interval Project 2000 (NORIP) collected serum, Li-heparin plasma, and EDTA buffy coat samples.
• Samples were sourced from over 3000 healthy individuals across 5 Nordic countries, ensuring diverse representation.
• These samples are cryopreserved below -80°C at the Nordic Reference Interval Project Bio-bank and Database (NOBIDA).

Purpose of the Study:

• To create a comprehensive bio-bank for clinical biochemistry research.
• To facilitate the development of new reference intervals for biochemical markers.
• To support the advancement of clinical chemistry in Nordic laboratories.

Main Methods:

• Collection of biological samples (serum, plasma, buffy coat) from a large, diverse healthy population.
• Cryopreservation of multiple aliquots from each individual at ultra-low temperatures (-80°C).
• Establishment of a database (NOBIDA) linking samples with demographic, clinical, and analytical data.

Main Results:

• A substantial bio-bank (NOBIDA) containing samples from approximately 3000 individuals is established.
• Commutable reference serum with certified values is available for quality control.
• Associated data on individuals, samples, and measurement systems are stored and managed.

Conclusions:

• The NOBIDA bio-bank represents a valuable, extensive resource for the Nordic clinical chemistry community.
• Researchers are encouraged to utilize this material for developing new reference intervals and advancing clinical biochemistry.
• The project supports ongoing research and development in diagnostic laboratory medicine.