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Characterisation of atopic and non-atopic wheeze in 10 year old children

R J Kurukulaaratchy1, M Fenn, S Matthews

  • 1The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight PO30 5TG, UK.

Thorax
|June 30, 2004
PubMed

Insights

Non-atopic wheeze is as common as atopic wheeze in 10-year-old children. However, atopic wheeze is more frequently treated, and distinct risk factors influence each type of wheeze.

Area of Science:

  • Pediatric respiratory health
  • Allergy and immunology
  • Epidemiology

Background:

  • Wheezing is prevalent in both atopic and non-atopic children.
  • Understanding distinct mechanisms of childhood wheeze is crucial for targeted interventions.

Purpose of the Study:

  • To assess characteristics of atopic and non-atopic wheeze in children at 10 years of age.
  • To identify differing underlying mechanisms and risk factors for each wheeze type.

Main Methods:

  • Prospective whole population birth cohort study (n=1456) with follow-up at 1, 2, 4, and 10 years.
  • Evaluated inherited and environmental risk factors, skin prick testing, spirometry, and methacholine bronchial challenge at 10 years.
  • Logistic regression identified independent risk factors for atopic and non-atopic wheeze.

Main Results:

  • Atopic (10.9%) and non-atopic (9.7%) wheeze were equally common at 10 years.
  • Atopic wheeze showed greater bronchial hyperresponsiveness and airways obstruction.
  • Maternal asthma and early infections predicted non-atopic wheeze; sibling asthma, eczema, rhinitis, and male sex predicted atopic wheeze.

Conclusions:

  • Non-atopic wheeze is as common as atopic wheeze in 10-year-olds.
  • Atopic wheeze is more frequently treated, despite similar current morbidity.
  • Distinct risk factor profiles are associated with atopic versus non-atopic wheeze.
Abstract

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