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Updated: Aug 23, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
[Leukaemia inhibitory factor (LIF): structure and biological activity]
Jacek Szepietowski1, Adam Reich
1Katedra i Klinika Dermatologii, Wenerologii i Alergologii Akademii Medycznej we Wrocławiu. jszepiet@derm.am.wroc.pl
Abstract:
Leukaemia inhibitory factor (LIF) is a multifunctional cytokine, which plays a role in growth-promotion and differentiation, regulates calcium and bone metabolism, induces acute phase proteins and causes cachexia in organisms with neoplastic disorders. Moreover, LIF participates in the induction of inflammation, and therefore represents an important pathogenic factor of many disorders. The multifunctional properties of LIF have become of special interest to investigators from different disciplines of medicine.
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