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Weight change and cognitive performance.

D Brubacher1, A U Monsch, H B Stähelin

  • 1Memory Clinic, Geriatric University Hospital, Basel, Switzerland. dorothee.brubacher@unibas.ch

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
|June 30, 2004
PubMed
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Weight changes in elderly citizens are linked to cognitive performance. Significant weight fluctuations may indicate cognitive decline or early neurodegenerative changes.

Area of Science:

  • Gerontology
  • Neuroscience
  • Public Health

Background:

  • Cognitive performance is crucial for elderly well-being.
  • Weight fluctuations are common in aging populations.
  • Understanding the link between weight and cognition is vital for health interventions.

Purpose of the Study:

  • To examine the association between body mass index (BMI) changes and cognitive function in older adults.
  • To determine if weight changes over time predict cognitive performance in the elderly.

Main Methods:

  • Analysis of the Basel Study cohort, including 531 healthy subjects.
  • Cognitive assessment using the Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery (CERAD-NAB).
  • Statistical analysis using binary logistic regression to evaluate the predictive power of annual BMI change on cognitive performance.

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Main Results:

  • Annual change in BMI (quadratic term) was significantly associated with cognitive performance (P<0.01).
  • ApoE genotype (P<0.05) and optimal health status (P<0.01) also remained significant predictors.
  • The study identified a quadratic relationship between weight change and cognitive outcomes.

Conclusions:

  • The extent of weight change in the elderly is associated with cognitive performance.
  • This association may reflect either a consequence of cognitive impairment or an early sign of neurodegenerative processes.
  • Further research is needed to elucidate the causal relationship between weight dynamics and cognitive decline.