Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemokinins and endokinins.

N M Page1

  • 1School of Animal and Microbial Sciences, The University of Reading, RG6 6AJ Reading, United Kingdom. sasnpage@reading.ac.uk

Cellular and Molecular Life Sciences : CMLS
|June 30, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental angiogenin inhibitor (ribonuclease inhibitor), a novel gene in pre-eclampsia.

Pregnancy hypertension·2015
Same author

Maternal tissue blood flow and oxygen saturation in pre-eclampsia and intrauterine growth restriction.

European journal of obstetrics, gynecology, and reproductive biology·2014
Same author

A novel hysteroscopic technique for the accurate biopsy of decidua parietalis and basalis.

Placenta·2012
Same author

Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia.

Molecular human reproduction·2006
Same author

Neurokinin B is a paracrine vasodilator in the human fetal placental circulation.

The Journal of clinical endocrinology and metabolism·2003
Same author

The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant.

Placenta·2001
Same journal

PHLDA1 knockdown exacerbates emphysema in COPD by attenuating proliferation of alveolar type II cells via modulating GLI1 nuclear translocation.

Cellular and molecular life sciences : CMLS·2026
Same journal

Single-Cell dissection of fibrodysplasia ossificans progressiva identifies SPP1 as a mediator of macrophage-fibroadipogenic progenitors crosstalk.

Cellular and molecular life sciences : CMLS·2026
Same journal

Ablation of the renal tubular gluconeogenic enzyme PCK1 drives AKI-to-CKD transition by negatively regulating the TGF-β/Smad3 signaling pathway.

Cellular and molecular life sciences : CMLS·2026
Same journal

LncRNA modulates Dpp-mediated wing development to influence flight in Aedes aegypti.

Cellular and molecular life sciences : CMLS·2026
Same journal

TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis.

Cellular and molecular life sciences : CMLS·2026
Same journal

PRMT5-Cacna1d axis maintains calcium homeostasis to regulate postnatal motor development in mice.

Cellular and molecular life sciences : CMLS·2026
See all related articles

The discovery of new tachykinins, like hemokinin-1 (HK-1), expands our understanding of these peptides beyond substance P (SP). These novel peptides may act as peripheral SP-like agonists, challenging current views of SP's roles.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Molecular Biology

Background:

  • Mammalian tachykinins, previously limited to substance P (SP), neurokinin A, and B, have expanded significantly.
  • The identification of the TAC4 gene has revealed numerous species-divergent tachykinins.

Purpose of the Study:

  • To detail the newly discovered tachykinin peptides and their implications.
  • To investigate the potential roles of these novel peptides as peripheral agonists.

Main Methods:

  • Peptide identification through gene discovery (TAC4).
  • Analysis of peptide expression and receptor selectivity.
  • Immunological cross-reactivity studies.

Main Results:

  • Several new tachykinins identified, including hemokinin-1 (HK-1), endokinin-1 (EK-1), and human variants (hHK-1).

Related Experiment Videos

  • These peptides show high selectivity and potency for the NK(1) receptor, similar to SP.
  • Strong cross-reactivity with SP antibodies suggests potential re-evaluation of SP's peripheral functions.

    • Conclusions:

    • The tachykinin family is larger and more complex than previously known.
    • Newly discovered tachykinins may serve as endogenous peripheral SP-like agonists.
    • Further research is needed to clarify the precise roles and distribution of SP and related peptides.