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A new alkaloid from Dysoxylum binectariferum.

Dong-Hui Yang¹, Shao-Qing Cai, Yu-Ying Zhao

¹Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China.

Journal of Asian Natural Products Research

|July 1, 2004

Summary

Researchers isolated rohitukine and a new alkaloid, rohitukine N-oxide, from Dysoxylum binectariferum stem bark. Rohitukine possesses anti-inflammatory and immunomodulatory properties, while the new compound

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Area of Science:

Natural Product Chemistry
Pharmacognosy
Medicinal Chemistry

Background:

Dysoxylum binectariferum is a plant source of bioactive compounds.
Rohitukine, isolated from this plant, exhibits anti-inflammatory and immunomodulatory activities.

Purpose of the Study:

To isolate and characterize chemical constituents from the stem bark of Dysoxylum binectariferum.
To identify novel compounds with potential therapeutic applications.

Main Methods:

Phytochemical investigation of Dysoxylum binectariferum stem bark.
Isolation and purification of compounds using chromatographic techniques.
Structure elucidation of isolated compounds via spectral data analysis (NMR, etc.).

Main Results:

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Two compounds were isolated: rohitukine (a known compound) and a new alkaloid, rohitukine N-oxide.
The structure of rohitukine N-oxide was determined using spectral evidence and comparison with rohitukine.
Rohitukine is confirmed to possess anti-inflammatory and immunomodulatory activities.

Conclusions:

The study successfully identified known and novel compounds from Dysoxylum binectariferum.
Rohitukine N-oxide represents a new chemical entity derived from this plant.
Further research into the pharmacological properties of rohitukine N-oxide is warranted.