Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[New methodologic approaches in antimalarial molecular research].

R Gozalbes1, N Mahmoudi, D Mazier

  • 1Laboratoire de Parasitologie-Mycologie (EA3520), Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France.

Medecine Tropicale : Revue Du Corps De Sante Colonial
|July 1, 2004
PubMed
Summary

Drug resistance in Plasmodium falciparum malaria necessitates new treatments. Computational methods, including in silico screening and genomic data, accelerate the discovery of novel antimalarial drugs and targets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Brain lesions].

La Revue de medecine interne·2016
Same author

Aspergillus PCR in serum for the diagnosis, follow-up and prognosis of invasive aspergillosis in neutropenic and nonneutropenic patients.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same author

Candida inconspicua and Candida norvegensis: new insights into identification in relation to sexual reproduction and genome organization.

Journal of clinical microbiology·2015
Same author

Definition of an HBsAg to DNA international unit conversion factor by enrichment of circulating hepatitis B virus forms.

Journal of viral hepatitis·2015
Same author

PCR-based detection of Toxoplasma gondii DNA in blood and ocular samples for diagnosis of ocular toxoplasmosis.

Journal of clinical microbiology·2014
Same author

In vitro combination of voriconazole and miltefosine against clinically relevant molds.

Antimicrobial agents and chemotherapy·2014

Area of Science:

  • Medicinal Chemistry
  • Computational Biology
  • Parasitology

Context:

  • Plasmodium falciparum malaria affects 500 million people annually.
  • Increasing drug resistance in tropical areas drives high malaria morbidity and mortality.
  • Traditional drug discovery methods face significant challenges with in vitro and in vivo malaria models.

Purpose:

  • To explore the utility of computational approaches for identifying new antimalarial drug targets and agents.
  • To address the limitations of conventional pharmacological research in malaria drug discovery.
  • To leverage advances in genomics and in silico modeling for antimalarial drug development.

Summary:

  • In silico methods, utilizing 2D/3D chemical structures and mathematical modeling, are effective for screening antimalarial activity.

Related Experiment Videos

  • These computational techniques facilitate virtual synthesis and the identification of drug-target interactions.
  • Integrating Plasmodium genomics enhances the performance of these tools for discovering new antimalarial drug targets.

    • Impact:

    • Accelerates the screening of large compound libraries for potential antimalarial drugs.
    • Provides a powerful alternative to traditional methods, overcoming limitations in malaria modeling.
    • Enhances the identification of novel therapeutic targets by combining computational chemistry with genomic insights.