Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tree-based model for breast cancer prognostication.

Mousumi Banerjee1, Julie George, Eun Young Song

  • 1Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109-2029, USA. mousumib@umich.edu

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|July 1, 2004
PubMed
Summary

This study identifies four breast cancer prognostic groups based on lymph node status, tumor size, and progesterone receptor status. These groups help guide patient management and clinical trial design for improved recurrence-free survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Priori Design, Combinatorial Synthesis, and Assessment of an Antipackaging Peptide Against Human Immunodeficiency Virus 1: Functional Role of Unnatural Trp Mimetics and Serendipitous Discovery of a Protease Inhibitor.

ChemMedChem·2026
Same author

Intragraft donor-specific antibodies reflect histologic heterogeneity in kidney allografts with concurrent serum DSA.

Frontiers in immunology·2026
Same author

Effects of acute warm-up intensity and baseline fitness on running performance in adolescents.

Frontiers in physiology·2026
Same author

Cellular engagement of the SARS-CoV-2 macrodomain by GS-441524 and enhanced <i>in vitro</i> inhibition by its diphosphorylated metabolite.

RSC chemical biology·2026
Same author

Reemerging kidney paired donation in Korea: simultaneous two-way swaps to overcome human leukocyte antigen and anatomic barriers.

Kidney research and clinical practice·2026
Same author

Toward a More Complete High-Resolution Human Leukocyte Antigen Reference for Koreans.

Annals of laboratory medicine·2026

Area of Science:

  • Oncology
  • Clinical Research
  • Biostatistics

Background:

  • Accurate prognostication is crucial for breast cancer management.
  • Identifying distinct prognostic groups can refine treatment strategies and clinical trial stratification.

Purpose of the Study:

  • To define prognostic groups for recurrence-free survival (RFS) in breast cancer.
  • To assess the relative impact of prognostic factors.
  • To examine treatment variations' influence on RFS within similar prognostic profiles.

Main Methods:

  • Analysis of 1,055 patients with stage I-III breast cancer (1990-1996).
  • Variables included socioeconomic factors, tumor characteristics, and treatment.
  • Multivariable analyses using recursive partitioning and Cox regression.

Related Experiment Videos

Main Results:

  • Four prognostic groups identified (5-year RFS: 97%, 78%, 58%, 27%) based on lymph node count, tumor size, PR status, differentiation, race, and marital status.
  • Best prognosis group (few nodes, small tumor, PR+, well-differentiated) RFS unaffected by adjuvant therapy.
  • Worst prognosis group (many nodes, PR-) benefited most from tamoxifen plus chemotherapy.

Conclusions:

  • Lymph node status, PR status, tumor size, differentiation, race, and marital status are key prognostic indicators.
  • Derived prognostic groups can inform clinical trial design and patient management strategies.
  • Treatment decisions may be optimized based on these prognostic groups.