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A new biologic prosthesis for vascular substitute in mongrel dogs
L A Marquez-Zacarias1, A R Rey, M C Heine
1Department of Surgery, Medical School, National University of Mexico, Mexico City.
Texas Heart Institute Journal
|September 1, 1985
Summary
New bovine pericardium vascular grafts show excellent patency and neoendothelialization in dogs. These glutaraldehyde-treated prostheses offer promising results for aortic repair without anticoagulation.
Area of Science:
- Biomaterials Science
- Vascular Surgery
- Veterinary Medicine
Background:
- Vascular prostheses are crucial for replacing damaged or diseased vessels.
- Bovine pericardium offers a promising source for bioprosthetic materials.
- Glutaraldehyde treatment is a common method for cross-linking and preserving biological tissues.
Purpose of the Study:
- To evaluate the efficacy and safety of glutaraldehyde-treated bovine pericardium vascular prostheses.
- To assess the long-term patency and biological response of these grafts in a canine abdominal aorta model.
Main Methods:
- Implantation of 29 glutaraldehyde-treated bovine pericardium vascular prosthesis tubes into the abdominal aortas of mongrel dogs.
- Observation period ranging from 30 to 540 days.
- Clinical evaluation, histologic examination, and arteriographic studies at study completion.
Main Results:
- High patency rate of 93.1% (27 out of 29 grafts) demonstrated by arteriography.
- Complete neoendothelialization observed in all implanted grafts.
- Mixed biological response including rejection and foreign body reaction noted from 180 days onwards.
- Excellent handling and consistency of grafts for surgical implantation.
- No need for graft procoagulation or animal anticoagulation.
Conclusions:
- Glutaraldehyde-treated bovine pericardium vascular prostheses exhibit excellent patency and promote neoendothelialization.
- These grafts are suitable for abdominal aortic replacement in dogs, demonstrating good surgical characteristics.
- The study suggests potential for these bioprostheses in vascular reconstruction without requiring systemic anticoagulation.