Related Experiment Video
Updated: Aug 23, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
M-mode and cross-sectional echocardiographic features of flail aortic leaflets
1Department of Internal Medicine, Case Western Reserve University, School of Medicine, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
Abstract:
The echocardiographic features in seven patients with flail aortic leaflets are described and are correlated with the anatomical appearance of the valve at the time of surgery or autopsy. M-mode echocardiography showed coarse and "shaggy" diastolic echoes within the aortic root and thickening of the aortic leaflets during systole in all patients. Six patients had coarse and "shaggy" diastolic echoes within the left ventricular outflow tract in continuity with similar echoes within the aortic root. Cross-sectional echocardiography in three patients revealed a cord-like mass prolapsing into the left ventricular outflow tract during diastole. Three of the patients had no vegetations at the time of surgery. Both modes of echocardiography are of value in demonstrating abnormal echoes prolapsing into the left ventricular outflow tract, characteristic of flail aortic leaflets that can occur in the presence or absence of vegetations.
Related Concept Videos
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Valve Prolapse I: Introduction

