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Effect of chronic administration of dexfenfluramine on blood pressure in salt-sensitive rats
N E Rowland1, M J Fregly, C M Poortman
1Department of Psychology, University of Florida, Gainesville 32611.
Life Sciences
|January 1, 1992
Abstract:
Chronic administration of dexfenfluramine, at a relatively low daily dose, slowed the development of salt-induced elevation of blood pressure in salt-sensitive (Dahl DS and Rapp SS) rats. This effect could not be accounted for by drug-related anorexia alone. Elevated serotonin activity, possibly in the brain, may underlie this antihypertensive action of dexfenfluramine.