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Serum changes in trace elements during thyroid cancers.

H Al-Sayer1, T C Mathew, S Asfar

  • 1Department of Surgery, Faculty of Medicine, Kuwait University Health Sciences Center, Safat, Kuwait.

Molecular and Cellular Biochemistry
|July 2, 2004
PubMed
Summary
This summary is machine-generated.

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Serum zinc levels decrease in thyroid cancer patients and normalize after surgery, suggesting zinc monitoring for surgical success and patient follow-up.

Area of Science:

  • Biochemistry
  • Oncology
  • Clinical Chemistry

Background:

  • Thyroid cancer is a significant health concern.
  • Trace elements play crucial roles in biological processes.
  • Alterations in trace element levels may indicate disease states.

Purpose of the Study:

  • To investigate the impact of thyroid cancer on serum and tissue trace element levels.
  • To assess the changes in trace elements following surgical intervention for thyroid cancer.

Main Methods:

  • Serum and thyroid tissue samples were collected from 43 thyroid cancer patients.
  • Trace element concentrations (Zn, Cu, Mn, Mg, Fe, Se) were measured pre- and post-surgery.
  • Results were compared to normal reference values.

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Main Results:

  • Serum zinc levels were significantly lower in thyroid cancer patients compared to normal subjects.
  • Post-operative serum zinc levels returned to normal.
  • Serum copper levels increased significantly after surgery.
  • Serum iron, magnesium, and manganese levels decreased significantly post-operatively.
  • No significant changes were observed in serum selenium levels.
  • Thyroid tissue concentrations of trace elements did not differ between cancerous and adjacent normal tissue.

Conclusions:

  • Decreased serum zinc levels are associated with thyroid cancer.
  • Monitoring serum zinc may serve as an indicator of successful thyroid cancer surgery.
  • Changes in serum zinc levels could be valuable for long-term follow-up of thyroid cancer patients.