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Critical evaluation of previously published data on the fractional urinary fluoride excretion in young children

Alberto E Villa1

  • 1Institute of Nutrition and Food Technology, University of Chile, Santiago. avilla@inta.cl

Community Dental Health
|July 2, 2004
PubMed

Insights

Young children’s fractional urinary fluoride excretion (FUFE) varies significantly. The inverse of fluoride dose, urinary fluoride excretion rate, and age are key predictors of FUFE in this age group.

Area of Science:

  • Pediatric Health
  • Environmental Health
  • Toxicology

Background:

  • Investigated the controversial findings on fractional urinary fluoride excretion (FUFE) in young children.
  • Compared total fluoride intake and urinary fluoride excretion in pediatric populations.

Purpose of the Study:

  • Analyze published data to understand how metabolic variables influence FUFE in children.
  • Explore the impact of fluoride dose (F-dose), urinary fluoride excretion rate, age, and body weight on FUFE values.

Main Methods:

  • Utilized bivariate correlations to analyze previously published average FUFE values in young children.
  • Employed multiple linear regression models to study individual FUFE values when available.

Main Results:

  • Average FUFE values in young children showed a linear correlation with the inverse of the daily F-dose (r = 0.90; p < 0.0005).
  • A multiple regression model predicted individual FUFE values with high accuracy (multiple R2 = 0.947; p < 0.0001) using the inverse of the dose, urinary fluoride excretion rate, and age.

Conclusions:

  • Young children do not exhibit a single average FUFE value; significant variability exists.
  • The inverse of the F-dose explains a substantial portion (81%) of FUFE variability.
  • Individual FUFE variability in young children is largely explained by the inverse F-dose, urinary fluoride excretion rate, and age (95%).
Abstract

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