Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute-to-chronic species sensitivity distribution extrapolation.

Cédric Duboudin1, Philippe Ciffroy, Hélène Magaud

  • 1EDF, Division Recherche et Développement, Département Laboratoire National d'Hydraulique et Environnement, 6 quai Watier, 78401 Chatou, France.

Environmental Toxicology and Chemistry
|July 3, 2004
PubMed
Summary

This study introduces an acute to chronic transformation (ACT) methodology to estimate chronic toxicity data when it is scarce, using abundant acute toxicity data and species sensitivity distributions (SSDs). The ACT approach accurately predicts chronic hazardous concentrations, improving substance risk assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulating synergism or antagonism in binary mixtures with different modeling approaches - A case study focused on the effect of disinfection by-products on algal growth.

The Science of the total environment·2025
Same author

Radionuclide sorption dynamics in the Rhone River: Experimental and modelling approach.

Journal of environmental radioactivity·2025
Same author

Sub-lethal toxicity of five disinfection by-products on microalgae determined by flow cytometry - Lines of evidence for adverse outcome pathways.

Ecotoxicology and environmental safety·2023
Same author

<sup>36</sup>Cl, a new tool to assess soil carbon dynamics.

Scientific reports·2023
Same author

A Novel Tool for Real-time Estimation of Epidemiological Parameters of Communicable Diseases Using Contact-Tracing Data: Development and Deployment.

JMIR public health and surveillance·2022
Same author

Modelling geochemical and kinetic processes involved in lead (Pb) remobilization during resuspension events of contaminated sediments.

The Science of the total environment·2019

Area of Science:

  • Environmental Toxicology
  • Ecotoxicology
  • Risk Assessment

Background:

  • Limited chronic toxicity data hinders accurate substance risk assessment.
  • Acute toxicity data is often more abundant than chronic data.
  • Species sensitivity distributions (SSDs) are valuable tools in ecotoxicology.

Purpose of the Study:

  • To develop and validate an acute to chronic transformation (ACT) methodology for estimating chronic toxicity values.
  • To utilize abundant acute toxicity data to predict chronic hazardous concentrations (HC5%) when chronic data are limited.
  • To assess the reliability of the ACT methodology by comparing predicted and real chronic HC5% values.

Main Methods:

  • Constructed an ACT methodology based on comparing acute and chronic species sensitivity distributions (SSDs) for vertebrate and invertebrate data.

Related Experiment Videos

  • Developed relationships to predict chronic toxicity values from acute data samples.
  • Calculated predicted chronic HC5% values using the ACT methodology.
  • Compared predicted chronic HC5% with real chronic HC5% for 11 test substances.

    • Main Results:

    • The ACT methodology successfully predicted chronic toxicity values from acute data.
    • For 11 substances, the ratio between real and ACT-predicted chronic HC5% averaged 1.6 and did not exceed 4.4.
    • The ACT approach provides a reliable method for estimating chronic HC5% when chronic data is scarce.

    Conclusions:

    • The developed ACT methodology effectively leverages acute toxicity data to estimate chronic toxicity.
    • This approach enhances the utility of available data for robust substance risk assessment.
    • The ACT methodology offers a practical solution for deriving chronic ecotoxicological endpoints in data-poor situations.