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Related Experiment Videos

Doxycycline-induced pill esophagitis.

A Kadayifci1, M T Gulsen, M Koruk

  • 1Department of Gastroenterology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. kadayifci@gantep.edu.tr

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
|July 3, 2004
PubMed
Summary
This summary is machine-generated.

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Pill-induced esophagitis, often from doxycycline, can cause chest pain and difficulty swallowing. Taking medication with sufficient water and upright can prevent these esophageal injuries.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Pill-induced esophagitis is a known adverse effect of certain medications.
  • Common culprits include tetracyclines and NSAIDs, but doxycycline is also implicated.

Observation:

  • This report details five cases of doxycycline-induced esophagitis in young to middle-aged women.
  • Symptoms included dysphagia, odynophagia, and retrosternal pain.
  • Endoscopic findings revealed esophageal injuries in the middle third with normal surrounding mucosa.

Findings:

  • All patients reported swallowing capsules with minimal water or while lying down.
  • Symptoms resolved within 2-7 days after drug cessation.
  • Follow-up endoscopies showed complete healing after 3-4 weeks.

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Implications:

  • Drug-induced esophagitis is not rare and should be considered in patients with chest pain and dysphagia.
  • Physicians should educate patients on proper medication intake (sufficient fluids, upright position) to prevent esophageal injury.