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Colonizing and invasive strains of Streptococcus pneumoniae in Uruguayan children: type distribution and patterns of

M C Mogdasy1, T Camou, C Fajardo

  • 1Maternal and Infant Care Program, Ministry of Public Health, Montevideo, Uruguay.

The Pediatric Infectious Disease Journal
|August 1, 1992
PubMed

Insights

This study investigated Streptococcus pneumoniae colonization in Uruguayan children. Serotype 14 was common in infections, and antibiotic resistance, particularly to cotrimoxazole, requires ongoing monitoring.

Area of Science:

  • Microbiology
  • Pediatrics
  • Epidemiology

Background:

  • Streptococcus pneumoniae is a leading cause of childhood respiratory infections.
  • Understanding colonization patterns is crucial for infection control and vaccine strategies.

Purpose of the Study:

  • To determine the frequency of Streptococcus pneumoniae colonization in Uruguayan children with acute respiratory infections (ARIs) and healthy controls.
  • To identify prevalent serotypes and assess antibiotic susceptibility of colonizing and invasive strains.

Main Methods:

  • Semiquantitative cultures of nasopharyngeal aspirates and throat swabs from children with ARIs and controls.
  • Serotyping of S. pneumoniae isolates.
  • Antibiotic susceptibility testing.

Main Results:

  • Colonization rates were higher in ambulatory patients (42.1%) than controls (15.2%) using nasopharyngeal aspirates.
  • Serotype 14 was predominant among invasive and colonizing strains.
  • 37.2% of invasive strains showed resistance to cotrimoxazole.

Conclusions:

  • This is the first study on S. pneumoniae colonization frequency in Uruguay.
  • Serotype 14 is a significant pathogen in Uruguayan children with ARIs.
  • Continuous surveillance of antibiotic susceptibility is necessary due to observed resistance patterns.

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