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Updated: May 9, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

New drugs for treatment of multiple myeloma

Benedetto Bruno1, Marcello Rotta, Luisa Giaccone

  • 1Division of Haematology, University of Turin, Department of Medicine and Experimental Oncology, Laboratory of Haematology and Oncology, Centro di Ricerca in Medicina Sperimentale, Ospedale San Giovanni Battista, Italy. benedetto.bruno@unito.it

The Lancet. Oncology
|July 3, 2004
PubMed

Insights

New therapeutic strategies targeting molecular mechanisms show promise for treating multiple myeloma (MM), a fatal plasma cell disease. Early clinical results for these novel agents in MM treatment regimens are encouraging.

Area of Science:

  • Oncology
  • Hematology
  • Molecular Biology

Background:

  • Multiple myeloma (MM) is a fatal plasma cell malignancy.
  • Understanding MM cell biology reveals molecular targets for therapy.
  • The bone marrow microenvironment significantly influences MM progression and drug resistance.

Purpose of the Study:

  • To discuss the mechanisms of action of novel therapeutic agents targeting molecular pathways in MM.
  • To review preliminary clinical outcomes of new MM treatment strategies.
  • To highlight advancements in rational drug design for multiple myeloma.

Main Methods:

  • Review of laboratory and preclinical studies on MM biology.
  • Analysis of molecular mechanisms targeted by new therapeutic agents.
  • Evaluation of preliminary clinical data from new MM treatment regimens.

Main Results:

  • New agents targeting specific molecular mechanisms show therapeutic potential.
  • Novel treatment strategies are being developed for both advanced and newly diagnosed MM.
  • Preliminary clinical outcomes for these new regimens are encouraging.

Conclusions:

  • Targeting molecular mechanisms offers a promising therapeutic avenue for multiple myeloma.
  • Continued research into novel agents and treatment strategies is crucial for improving MM outcomes.
  • The integration of molecularly targeted drugs represents a significant advancement in MM therapy.

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