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Updated: Aug 23, 2026

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Manipulating dendritic cell biology for the active immunotherapy of cancer
David W O'Neill1, Sylvia Adams, Nina Bhardwaj
1New York University School of Medicine, 550 1st Ave, MSB 507, New York, NY 10016, USA.
Abstract:
Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have an unequaled capacity to initiate primary immune responses, including tolerogenic responses. Because of the importance of DCs in the induction and control of immunity, an understanding of their biology is central to the development of potent immunotherapies for cancer, chronic infections, autoimmune disease, and induction of transplantation tolerance. This review discusses recent advances in DC research and the application of this knowledge toward new strategies for the clinical manipulation of DCs for cancer immunotherapy.
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