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Epidemiological markers of group A streptococcal infections in France

Julien Loubinoux1, Martine Florent, Bensalem Merad

  • 1Centre National de Référence des Streptocoques - Service de Microbiologie, Hôtel Dieu Assistance Publique - Hôpitaux de Paris, Université Paris VI, 1 place du Parvis Notre-Dame, F-75181 Paris Cedex 04, France. j.loubinoux@viola.fr

The Indian Journal of Medical Research
|July 3, 2004
PubMed
Abstract

Insights

Group A Streptococcus invasive isolates are frequently linked to biotype 1, T-type 1, and emm-type 1. Non-invasive strains often show T-type 28 and emm-type 28, crucial for understanding epidemiology and vaccine development.

Area of Science:

  • Microbiology
  • Epidemiology
  • Infectious Diseases

Background:

  • Certain Group A Streptococcus (GAS) biotypes, T-types, and emm-types are associated with invasive infections.
  • The M protein of GAS is vital for virulence and serves as an important epidemiological marker.

Purpose of the Study:

  • To compare epidemiological markers in invasive and non-invasive clinical isolates of Group A Streptococcus.
  • To identify specific T-types and emm-types prevalent in invasive versus non-invasive GAS infections in France.

Main Methods:

  • A study was conducted in France between 1998 and 2001.
  • 141 invasive and 353 non-invasive GAS isolates were analyzed.
  • Biotype, T-type, and emm-type were determined for all isolates.

Main Results:

  • Invasive isolates were primarily from blood, while non-invasive isolates were from throat swabs.
  • Biotype 1 was common in most isolates.
  • Invasive isolates were predominantly T-type 1/emm-type 1, with T-type 4/emm-type 4 and T-type 28/emm-type 28 also frequent.
  • T-type 28/emm-type 28 was common in invasive isolates causing puerperal sepsis and in non-invasive isolates.

Conclusions:

  • The study confirms a high prevalence of biotype 1, T-type 1, and emm-type 1 among invasive GAS isolates.
  • emm-type 28/T-type 28 was frequently found in non-invasive GAS isolates.
  • Ongoing prospective studies will update emm-type prevalence in France, aiding future vaccine development.

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