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Related Experiment Videos

Susceptibility testing of Streptococcus mitis group isolates.

G Bancescu1, S Dumitriu, A Bancescu

  • 1Chair of Microbiology, University of Medicine & Pharmacy "Carol Davila", Romania.

The Indian Journal of Medical Research
|July 3, 2004
PubMed
Summary

Antimicrobial susceptibility testing of oral streptococci in Romania revealed resistance to common antibiotics. Clindamycin and chloramphenicol show promise for treating oral infections caused by resistant bacteria.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Suppurative oral and maxillofacial infections are often polymicrobial, involving aerobic and anaerobic bacteria, with oral streptococci being frequent culprits.
  • Effective antimicrobial treatment is crucial for managing these infections, necessitating an understanding of bacterial susceptibility patterns.

Purpose of the Study:

  • To investigate the antimicrobial susceptibility profiles of Streptococcus mitis group strains.
  • To analyze isolates from Romanian patients diagnosed with various oral and maxillofacial infections.

Main Methods:

  • Identification of 85 Streptococcus mitis group isolates from 151 pus samples using the Rapid ID 32 STREP system.
  • Determination of minimum inhibitory concentrations (MICs) via E test for penicillin, ampicillin, cefotaxime, erythromycin, clindamycin, chloramphenicol, and tetracycline.

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Main Results:

  • MIC values for penicillin ranged from 0.016-0.75 mg/l, ampicillin 0.016-2 mg/l, cefotaxime 0.016-1 mg/l, erythromycin 0.016-4 mg/l, clindamycin 0.016-0.047 mg/l, chloramphenicol 0.5-4 mg/l, and tetracycline 0.047-256 mg/l.
  • Significant variation in susceptibility was observed across the tested antibiotics, with notable resistance patterns.

Conclusions:

  • The study highlights a concerning low susceptibility and resistance to commonly used antibiotics among oral streptococci isolates.
  • Continuous surveillance of antibiotic susceptibility is essential for guiding effective clinical treatment strategies.
  • Clindamycin and chloramphenicol emerge as potential alternative agents for treating oral and maxillofacial infections, particularly those involving penicillin-resistant strains or in patients with beta-lactam hypersensitivity.