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Updated: Aug 19, 2026

Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
Published on: January 16, 2013
[Endothelin system and inhalation of iloprost in pulmonary hypertension]
1Klinik für Anaesthesiologie und Intensivmedizin, Universitätskliniken des Saarlandes, Homburg/Saar. michael.bauer@med.uni-jena.de
Abstract:
The haemodynamics and vascular proliferation (remodelling) in pulmonary hypertension are unfavourably affected by a malfunction of the endothelial cells of the pulmonary vessels. A characteristic result is reduced formation of endothelial dilators and increased formation of vasoconstrictors. The favourable effects of a blockade of the endothelin (ET) system with receptor antagonists suggest that the increased formation and limited clearance of ET-1 reaches pathogenetic significance. The therapeutic effects of inhaled iloprost on right cardiac haemodynamics and clinical course, could in addition to the direct vasodilatory effect, also be considered to have a favourable influence on the ET system as a pathophysiologically effective mediator system.
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