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[Autonomic nervous system function in cardiologic syndrome X].
Agata Furgała1, Władysława Kolasińska-Kloch, Małgorzata Kloch
1Katedra Patofizjologii Collegium Medicum Uniwersytetu Jagiellońskiego ul. Czysta 18, 31-121 Kraków. afurgala@cm-uj.krakow.pl
Folia Medica Cracoviensia
|July 6, 2004
Summary
Syndrome X, characterized by chest pain and normal coronary arteries, may stem from autonomic nervous system dysfunction. Some patients exhibit abnormal heart rate regulation, potentially due to sympathetic overactivity or reduced parasympathetic tone.
Area of Science:
- Cardiology
- Autonomic Nervous System Research
- Clinical Medicine
Context:
- Syndrome X, also known as cardiac syndrome X, presents with typical angina pectoris.
- Patients exhibit a positive treadmill exercise test but a negative intravenous ergonovine test.
- Coronary arteries appear normal upon angiography, complicating diagnosis and understanding.
Purpose:
- To investigate the potential role of autonomic nervous system (ANS) dysfunction in the pathogenesis of Syndrome X.
- To explore the heterogeneity of ANS activity within the Syndrome X patient population.
- To identify specific patterns of autonomic dysregulation, such as sympathetic overactivity or reduced parasympathetic activity.
Summary:
- Syndrome X patients display varied autonomic nervous system activity.
- Approximately 40% of patients show normal autonomic regulation of heart function.
- A significant 60% exhibit abnormal autonomic regulation, possibly linked to high sympathetic drive or low parasympathetic activity.
Impact:
- This research highlights the importance of assessing autonomic function in Syndrome X diagnosis and management.
- Understanding ANS alterations may lead to targeted therapeutic strategies for chest pain relief.
- Further research into the specific mechanisms of autonomic dysregulation can improve patient outcomes.