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Updated: Aug 23, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Enteritis as a complication of adjuvant combination chemotherapy using 5-fluorouracil and leukovorin: clinical and
Ramin Zamani1, Maureen Heldmann
1Department of Radiology, Louisiana State University Health Sciences Center, Shreveport, USA.
Abstract:
The combination of 5-flourouracil (5-FU) and leukovorin is widely used as adjuvant chemotherapy for metastatic colorectal carcinoma. The most common clinical side effects of 5-FU are related to its gastrointestinal toxicity, chiefly stomatitis and diarrhea. The latter may be severe in up to 30% and occasionally is life-threatening. We describe a case of therapy-induced enteritis presenting as acute abdominal pain and present the computed tomographic (CT) findings. In light of the prevalence of this regimen, the potential morbidity of this complication, and a paucity of CT examples in the radiologic literature, this case illustrates an important adverse effect of this medication. Early recognition and treatment should avoid significant morbidity and mortality.
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