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[The Philadelphia chromosome 30 years later]
1Departamento de Genética, Instituto Nacional de la Nutrición Salvador Zubirán, D.F., México.
Abstract:
We review the changing concepts regarding the nature of the Ph chromosome during the last thirty years. The role of molecular biology techniques in its identification are discussed as well as its present status in the diagnosis, prognosis and management of chronic myelogenous leukemia and acute lymphoblastic leukemia.