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Updated: Feb 10, 2026
09:02
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
Published on: June 5, 2020
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Common genotypes of hepatitis B virus
Muhammad Idrees1, Sanaullah Khan, Sheikh Riazuddin
1Division of Infectious Disease and Molecular Diagnostics, National Centre of Excellence in Molecular Biology, University of Punjab, Lahore. idrees_khan@lycos.co.uk
Summary
This study identified four common hepatitis B virus (HBV) genotypes (A, B, C, and D) in Pakistan, with genotype C being the most prevalent. Regional variations in genotype distribution were observed across Sindh, Punjab, and N.W.F.P.
Area of Science:
- Virology
- Molecular Biology
- Infectious Diseases
Background:
- Hepatitis B virus (HBV) infection is a significant global health concern.
- Understanding HBV genotype distribution is crucial for effective treatment and prevention strategies.
- Previous studies have indicated regional variations in HBV genotypes.
Purpose of the Study:
- To determine the frequency of common hepatitis B virus (HBV) genotypes in a Pakistani population.
- To identify the predominant HBV genotypes circulating in the study area.
- To analyze the geographical distribution of HBV genotypes within Pakistan.
Main Methods:
- An analytical study was conducted using a molecular genotyping system based on PCR.
- 112 HBV DNA positive sera were analyzed using type-specific primers for HBV genotypes A through H.
- The study was performed at the Centre for Applied Molecular Biology, Lahore, Pakistan, from May 2002 to February 2004.
Main Results:
- Four HBV genotypes (A, B, C, and D) were identified among the 112 samples.
- Hepatitis B virus genotype C was the most predominant, found in 41.07% of cases.
- Genotype A was predominant in Sindh (68%), genotype C in N.W.F.P. (68.96%), and genotypes C and B in Punjab (39.65% and 25.86%, respectively).
- Mixed genotypes were detected in 7.14% of isolates.
Conclusions:
- The study successfully isolated four common HBV genotypes (A, B, C, and D), consistent with worldwide distribution.
- Hepatitis B virus genotype C emerged as the predominant genotype in the studied population.
- Significant regional variations in genotype prevalence were observed, with genotype A dominant in Sindh and genotypes B and C prevalent in Punjab and N.W.F.P.
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