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Related Experiment Videos

Low dose hyper-radiosensitivity in metastatic tumors.

Jackie Harney1, Susan C Short, Nihal Shah

  • 1Marie Curie Research Wing, Mount Vernon Hospital, Northwood HA6 2RN, UK. dr_harney@yahoo.com

International Journal of Radiation Oncology, Biology, Physics
|July 6, 2004
PubMed
Summary

Low dose hyper-radiosensitivity (LDHRS) was observed in clinical tumors. Ultrafractionated radiotherapy significantly increased tumor growth delay in radioresistant cancers, suggesting a potential new treatment strategy.

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Area of Science:

  • Radiation Oncology
  • Cancer Biology
  • Clinical Trials

Background:

  • Low dose hyper-radiosensitivity (LDHRS) is a phenomenon of increased cancer cell kill below 1 Gy.
  • This effect deviates from the standard linear-quadratic model predictions.
  • Clinical exploitation of LDHRS is under investigation.

Purpose of the Study:

  • To investigate the clinical relevance of low dose hyper-radiosensitivity (LDHRS).
  • To evaluate the efficacy of ultrafractionated radiotherapy in treating tumors exhibiting LDHRS.
  • To compare tumor growth delay between conventionally and ultrafractionated radiotherapy regimens.

Main Methods:

  • Patients with metastatic skin nodules were enrolled in a randomized trial.
  • Tumor nodules were treated with either conventional (1.5 Gy/day) or ultrafractionated (0.5 Gy TDS) radiotherapy.

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  • Tumor volume changes and time to regrowth were monitored and analyzed.

    • Main Results:

    • Analysis included 36 evaluable nodules from 8 patients.
    • Ultrafractionated radiotherapy showed a trend towards improved outcomes (p=0.14).
    • Radioresistant tumors known to exhibit LDHRS showed a statistically significant benefit with ultrafractionated radiotherapy (p=0.009).

    Conclusions:

    • Low dose hyper-radiosensitivity (LDHRS) is demonstrable in clinical settings.
    • Ultrafractionated radiotherapy significantly enhances tumor growth delay in radioresistant malignant tumors.
    • This suggests a promising clinical application for LDHRS-based treatment strategies.