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Stress, hormones and disease.
1War Related Illness and Injury Center, New Jersey VA Health Care System and Department of Neurosciences, New Jersey Medical School, East Orange, NJ 07018, USA. bhn@njneuromed.org
Physiology & Behavior
|July 6, 2004
Summary
Stress impacts health, with motor behaviors better indicators than hormones like catecholamines or glucocorticoids. Stress exacerbates existing conditions and is linked to medically unexplained fatigue, distinct from posttraumatic stress disorder (PTSD).
Area of Science:
- Behavioral Medicine
- Psychoneuroimmunology
- Stress Physiology
Background:
- Investigated hormones (catecholamines, glucocorticoids) as stress indicators, finding motor behaviors superior.
- Examined stress's role in disease development and exacerbation, noting profound effects on pre-existing conditions.
Discussion:
- Shifted focus to medically unexplained fatigue and pain, particularly in Gulf War veterans.
- Addressed the link between unexplained fatigue and posttraumatic stress disorder (PTSD).
Key Insights:
- Catecholamines are better indicators of aroused behaviors than glucocorticoids.
- Stress can induce illness but significantly worsens existing diseases.
- Medically unexplained fatigue in veterans is stress-sensitive but distinct from PTSD.
Outlook:
- Further research into the distinct pathways of stress-related disorders.
- Developing targeted interventions for medically unexplained symptoms.
- Understanding the neurobiological underpinnings of stress and disease.
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