The adventures of a "different" pair

Paul R McHugh1

  • 1Department of Psychiatry and Behavioral Science, School of Medicine, Johns Hopkins University, Meyer 127, 600 N. Wolfe St., Baltimore, MD 21287, USA. pmchugh@mail.jhmi.edu

Summary

This narrative explores the early careers of Gerry Smith and Paul McHugh in physiology and behavior. It details their initial collaboration and the challenges they faced during their formative years.

Related Concept Videos

Crossing Over01:34

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
Crossing over01:34

Crossing over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
Crossing Over01:30

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I, duplicated...
Work of a Couple Moment01:12

Work of a Couple Moment

Mechanical engineering involves the study of motion, energy, and force, and is concerned with designing, manufacturing, and maintaining mechanical systems. One important concept in this field is the couple moment, produced by two equal and opposite forces acting at two points in a rigid body separated by a certain distance.
When the rigid body undergoes a differential displacement due to a couple, its motion can be divided into two parts: equal translation of the two points to their final...
Couple01:29

Couple

A couple is a pair of parallel forces equal in magnitude but in opposite directions. The forces are separated by a perpendicular distance, known as the couple's arm. The couple causes a rotation force or moment that rotates the body about an axis perpendicular to the plane of the forces. The resulting moment is referred to as the couple moment. The SI unit of a couple moment is the Newton-meter (N-m).
A typical example to understand this concept is tightening a bolt with a lug wrench. A force...
Equivalent Couples01:28

Equivalent Couples

In mechanical engineering, the concept of equivalent couples plays a crucial role in understanding and analyzing various mechanical systems.
Two couples are considered to be equivalent if they produce the same rotational effect on a rigid body. In other words, the two couples have the same magnitude and act in the same direction, causing the same angular displacement or acceleration in the body.
For instance, consider two couples lying in the plane of the page, with one having a pair of equal...