Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thrombocytopenia in malaria.

S Looareesuwan1, J G Davis, D L Allen

  • 1Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|March 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A parsimonious alternative to the pacemaker/accumulator process in animal timing.

Behavioural processes·2014
Same author

A pediatrician's approach to counseling families of mentally retarded children.

Pediatric annals·2014
Same author

Plasma matrix metalloproteinase-9 response to downhill running in humans.

International journal of sports medicine·2013
Same author

Sensitivity of assays for the detection of HPA-1a antibodies: results of an international workshop demonstrating the impact of cation chelation from integrin αIIbβ3 on three widely used assays.

Vox sanguinis·2013
Same author

Hair testing for "ecstasy" (MDMA) in volunteer Scottish drug users.

Addiction biology·2010
Same author

The reactions of streptococci and lactobacilli in blood agar.

The Journal of hygiene·2010

Malaria infection is linked to low platelet counts, but this study found no evidence of antibodies causing this drop. This suggests non-immune factors are responsible for malaria-related thrombocytopenia.

Area of Science:

  • Immunology
  • Hematology
  • Infectious Diseases

Background:

  • Thrombocytopenia (low platelet count) is a common complication in Plasmodium falciparum and Plasmodium vivax malaria.
  • The exact mechanisms causing malaria-associated thrombocytopenia are not fully understood, with both immune and non-immune factors proposed.

Purpose of the Study:

  • To investigate the relationship between platelet counts and serum concentrations of direct (platelet bound) and indirect (platelet directed) antibodies in patients with malaria.
  • To determine if an immunological mechanism, specifically antibody-mediated platelet destruction, contributes to thrombocytopenia in malaria.

Main Methods:

  • Studied 17 patients with Plasmodium falciparum malaria and 12 patients with Plasmodium vivax malaria.
  • Measured absolute platelet counts during infection and recovery.

Related Experiment Videos

  • Assessed concentrations of direct and indirect platelet-specific antibodies in patient serum.

    • Main Results:

    • Platelet counts significantly increased with recovery from malaria infection in both P. falciparum and P. vivax groups (p < 0.002).
    • No correlation was found between absolute platelet counts or changes in platelet counts and the levels of direct or indirect platelet antibodies.
    • This indicates that antibody levels do not explain the observed thrombocytopenia in malaria patients.

    Conclusions:

    • The pathogenesis of thrombocytopenia in malaria is likely mediated by non-immunological mechanisms.
    • Further research is needed to elucidate the specific non-immune pathways involved in malaria-induced platelet reduction.