Anticarcinogenic activity of Withania somnifera Dunal against Dalton's ascitic lymphoma

Area of Science:

• Pharmacology and Toxicology
• Cancer Research
• Natural Product Chemistry

Background:

• Dalton's Ascitic Lymphoma (DAL) is an aggressive cancer model.
• Withania somnifera (Ashwagandha) is a medicinal herb with potential anti-cancer properties.
• Investigating natural compounds for cancer therapy is crucial.

Purpose of the Study:

• To evaluate the anti-cancer efficacy of ethanolic root extract of Withania somnifera (REWS).
• To assess the effect of REWS on Dalton's Ascitic Lymphoma (DAL) in vivo.
• To determine the impact of REWS on survival and hematological parameters in tumor-bearing mice.

Main Methods:

• Swiss albino mice were induced with Dalton's Ascitic Lymphoma.
• Tumor-induced mice were treated with ethanolic extract of Withania somnifera root (REWS).
• Survival time, tumor weight, cancer cell count, and hematological parameters were analyzed.

Main Results:

• REWS significantly increased the lifespan of tumor-bearing mice.
• Treatment with REWS led to a notable decrease in tumor weight and cancer cell number.
• REWS corrected aberrant hematological parameters in mice with Dalton's Ascitic Lymphoma.

Conclusions:

• Ethanolic extract of Withania somnifera root (REWS) demonstrates significant anti-cancer activity against Dalton's Ascitic Lymphoma.
• REWS exhibits a protective effect by improving survival and normalizing blood parameters.
• These findings support the therapeutic potential of Withania somnifera in cancer treatment.