Related Experiment Video
Updated: Aug 19, 2026

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
Percutaneous delivery of carbamazepine and selected N-alkyl and N-hydroxyalkyl analogues
L Fourie1, J C Breytenbach, J Du Plessis
1School of Pharmacy, North-West University, Potchefstroom 2520, South Africa.
Abstract:
Advantages associated with the transdermal delivery route are well documented, but in the past scientists have concentrated primarily on means of decreasing the barrier function of the skin for improved permeability. Pro-drugs, which possess more favourable physicochemical properties for improved transdermal permeability may have considerable potential. These have been considered in the past but recent information concerning structure activity relationships in dermal penetration has prompted increased interest. During this study, N-methyl (2), N-ethyl (3) and N-(2-hydroxyethyl) carbamazepine (4) analogues were synthesised for transdermal evaluation.
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