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Updated: Aug 23, 2026
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
Published on: April 3, 2011
Thymoma: a pathological study of 50 cases
Pradeep Vaideeswar1, A Padmanabhan, J R Deshpande
1Department of Pathology (Cardiovascular and Thoracic Division), Seth G. S. Medical College, Mumbai, India. shreeprajai@yahoo.co.in
Background:
A combination of epithelial cells and lymphocytes results in a varied histomorphology of thymomas and consequent varied classification systems.
Aim:
To correlate the Marino and Muller-Hermelink (MMH) classification with the invasive behaviour of thymomas.
Setting And Design:
Retrospective analysis.
Materials And Method:
Thymomas encountered in the past 21 years were re-classified with the MMH classification and correlated with Masaoka's staging and clinical presentation.
Results:
The thymomas formed 91% of the primary thymic epithelial tumours. Predominantly cortical thymomas (n=21) and cortical thymomas (n=22) were the common subtypes and 60% and 77% of these, respectively, were in stages II or III. Cystic change, necrosis or haemorrhage played no role in predicting invasive behaviour. Cortical epithelium correlated well with the presence of para-thymic syndromes, especially myasthenia gravis.
Conclusion:
MMH classification is easy to apply. Cortical thymomas in stage I should be followed up for possible recurrence.
